The Right Ventricle: A Not-So-Innocent Bystander in Pulmonary Hypertension Due to Left Heart Disease
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چکیده
“After all, there are no innocent bystanders . . . what are they doing there in the first place?” —William S. Burroughs, “Exterminator!” The most common disease associated with high pulmonary vascular pressures and right ventricular (RV) afterload is left heart disease (LHD). In this review, we will discuss the role right heart disease (RHD) plays in LHD progression, prognosis, and treatment. We will first discuss the current definitions employed in RHD and its epidemiology in various left heart diseases. We will next explore the pathophysiology of RV dysfunction in LHD, including a discussion of the effects and components of RV afterload and RV/left ventricular contractile interactions. Finally, we will describe the recently observed clinical implications of RV dysfunction in LHD and pertinent therapeutic considerations.
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تاریخ انتشار 2016